Journal: Molecules
Article Title: Design, Synthesis, and Antiproliferative Activity of Benzopyran-4-One-Isoxazole Hybrid Compounds
doi: 10.3390/molecules28104220
Figure Lengend Snippet: In vitro cytotoxicity of benzopyran-4-one-isoxazole conjugates (at a concentration of 25 μM) towards ( a ) human leukemia carcinoma (CCRF-CEM), ( b ) human ovarian adenocarcinoma (SKOV-3), ( c ) human breast tumor (MDA-MB-231), ( d ) human prostate cancer (PC-3), ( e ) androgen-independent human prostate cancer (DU-145), and ( f ) human renal carcinoma (iSLK) cell lines using DMSO and standard anticancer drug doxorubicin (Dox) (at a concentration of 5 μM) as controls after 24 and 72 h. The results are shown as the percentage of control that has no compound (set at 100%). All the experiments were performed in triplicate.
Article Snippet: The in vitro cytotoxicity of the conjugates was evaluated using six human cancer cell lines, one human normal kidney cell line, and one mammalian normal kidney cell line, which included human leukemia carcinoma cell lines (CCRF-CEM), human ovarian adenocarcinoma cell lines (SKOV-3), human breast tumor cell lines (MDA-MB-231), human prostate cancer cell lines (PC-3), androgen-independent human prostate cancer cell lines (DU-145), human renal carcinoma (iSLK), human embryonic kidney cell lines (HEK-293), and normal mammalian kidney cell line (LLCPK) to determine the toxicity of the synthesized conjugates.
Techniques: In Vitro, Concentration Assay, Control